Flow dependent elimination
WebB. Flow-Dependent Elimination. In contrast to capacity-limited drug elimination, some drugs are cleared very readily by the organ of elimination, so that at any clinically realistic concentration of the drug, most of the drug in the blood perfusing the organ is eliminated on the first pass of the drug through it. The elimination of these drugs ... WebThe rest of this subsection is adapted from Ref. [6] and it contains the loop transformation examples, which translate the loop-carried dependences form to the dependence-free …
Flow dependent elimination
Did you know?
WebThe elimination is constant because it is limited by the capacity of the channels. In converse, first-order elimination is proportional to the drug concentration, where a … Webrelated (R2=0.998, Figure 2) to the difference in meniscus elevation in a dependent loop in urine drainage tubing. CONCLUSION Dependent loops are associated with CAUTI [1] …
WebAfter i.v. administration, the decline in drug concentrations is biphasic and the drug is cleared very efficiently by the liver, so that its elimination is dependent largely on liver blood flow. Although the drug is some 90-95% bound to plasma, hepatic removal is so avid that both bound and free forms are extracted. WebDrug elimination systems are not saturated -- therefore the absolute rate of elimination is a linear function of the drug's plasma concentration. ... Saturable, dose-or concentration-dependent; Nonlinear; If blood flow to …
Web-sensitive to hepatic blood flow (flow dependent). -An increase in hepatic blood flow will increase the rate of drug removal by the liver. -Propranolol decreases hepatic blood flow and thus decreases its own clearance through the liver when given orally. -change in hepatic enzyme activity has less effects on hepatic clearance of these drugs. Webconcentration dependent clearance is a mixed order elimination process. Concentration independent, concentration dependent and flow dependent clearance are not exclusive properties. A drug can be eliminated by a combination of these processes. Note that although first-order clearance is constant the rate of elimination still varies with ...
WebElimination of the effects of convection can be effected as follows: (a) by limiting the aper- ture through a tube arrangement, e.g., to 5°-10°; (b) by providing an envelope transparent to the atmospheric radiation and at effectively the same temperature as the receiver; (c) by providing an artificial heat loss so great as to swamp the effect ...
WebFree drug almost completely extracted in the 1st pass. What does flow- dependent elimination depend on. Depends primarily on the rate of drug delivery. Blood flow is the … inch shapeWebDrug elimination in the body involves many complex rate processes. Although organ systems have specific functions, the tissues within the organs are not structurally homogeneous, and elimination processes may vary in each organ. In Chapter 4, drug elimination was modeled by an overall first-order elimination rate process. In this … inch shelf unitWebAug 23, 2024 · These drugs have a rapid uptake and high capacity, so elimination is perfusion dependent. Free drug is rapidly removed from plasma, bound drug is released … income tax on 380000WebAlso called flow dependent elimination: in this case most of the drug in the blood is eliminated on the first pass of the drug through the organ ... Michaelis-Menten elimination; If blood flow to the organ does not limit elimination, the relationship between the … Practice question set #8 (Opioid Metabolism and Drug Elimination) Practice question … inch shelvesWebSep 11, 2012 · Flow Dependent Elimination depends on the rate of delivery of drug to the organ of elimination CLorgan = Blood flow x Extraction Ratio = Q x ER = Q x Ci – CO Ci 30. D. Plasma Protien binding & Blood Cell partitioning • Plasma Protein binding may be important for extensively bound drugs: Phenytoin 89%, Salicylic acid 85% (Aspirin 49%) … income tax on 400 a weekWebB. Flow-Dependent Elimination. In contrast to capacity-limited drug elimination, some drugs are cleared very readily by the organ of elimination, so that at any clinically … income tax on 35000 annual incomeWebBlood flow through the organ is referred to as Q (mL/minute) as seen in Figure 2-6, where C in is the drug concentration in the blood entering the organ and out C is the drug concentration in the exiting blood. If the organ eliminates some of the drug, C in is greater than C out. Elimination over time Initial concentration Resulting ... income tax on 40000