WebFeb 22, 2015 · Malignant infantile osteopetrosis is a rarely seen severe disorder which appears early in life with general sclerosis of the skeleton. It is caused by functionally defective osteoclasts which fail to resorb bone. Affected infants can exhibit a wide spectrum of clinical manifestations including impaired hematopoiesis, hepatosplenomegaly, visual … WebOsteoclast activity is intimately involved in both the osteolytic bone metastases and humoral hypercalcemia of malignancy, two frequently presented pathologic complications …
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An osteoclast (from Ancient Greek ὀστέον (osteon) 'bone', and κλαστός (clastos) 'broken') is a type of bone cell that breaks down bone tissue. This function is critical in the maintenance, repair, and remodeling of bones of the vertebral skeleton. The osteoclast disassembles and digests the composite of hydrated … See more An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have five nuclei and are 150–200 µm in diameter. When osteoclast-inducing cytokines are used to convert macrophages to … See more Since their discovery in 1873 there has been considerable debate about their origin. Three theories were dominant: from 1949 to 1970 the connective tissue origin was popular, which … See more An osteoclast can also be an instrument used to fracture and reset bones (the origin is Greek osteon: bone and klastos: broken). To avoid confusion, the cell was originally termed … See more Osteoclasts were discovered by Kolliker in 1873. See more Once activated, osteoclasts move to areas of microfracture in the bone by chemotaxis. Osteoclasts lie in small cavities called Howship's lacunae, … See more An odontoclast (/odon·to·clast/; o-don´to-klast) is an osteoclast associated with absorption of the roots of deciduous teeth. See more Giant osteoclasts can occur in some diseases, including Paget's disease of bone and bisphosphonate toxicity. In cats, abnormal … See more WebJan 5, 2013 · The osteoblasts move over the matrix of a bone and deposit a protein mixture called osteoid. The osteoid contains a protein called collagen as its major component. … fha max mortgage amount 2021
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WebNov 9, 2009 · The same process associated with multiple-organ manifestations of Gsα mutation is referred to as McCune-Albright syndrome. ... In addition to the osteomalacic changes, fibrous dysplastic bone shows increased osteoclastic activity, and markers of bone resorption may be elevated in some affected persons . WebDue to these bioactivities that affect pathogenetic factors of osteoporosis, LithoLexal® Bone is referred to as a disease-modifying adjunctive therapy (DMAT). In postmenopausal animal models, LithoLexal® monotherapy preserved bone mineral density, ... Changes in the urinary level of a biomarker of osteoclastic activity, ... WebThese cell types occur in areas referred to as bone remodelling units [33]. Bone remodelling is the result of the coordinated action of bone-resorbing osteoclasts and bone-forming … fha max mortgage amount