WebbATF4. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … Webb1 mars 2024 · The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, …
Tissue expression of ATF4 - Summary - The Human Protein Atlas
Webb12 apr. 2024 · Background: Tocotrienol, a type of vitamin E, is well known for its anti-cancer and other biological activities. This systematic review aims to summarize the involvement of endoplasmic reticulum stress (ERS) and subsequent unfolded protein response (UPR) as the underlying molecular mechanisms for the anticancer properties of tocotrienol. … WebbTXLNG overexpression had no effect on ATF4 protein levels, while ATF4 overexpression increased ATF4 protein levels. Furthermore, ATF4 overexpression notably abolished the improvements in IR adipocyte dysfunction caused by TXLNG overexpression. In conclusion, TXLNG improves IR in obese subjects in vitro and in vivo by inhibiting ATF4 ... ford angers occasions
A naturally-occurring protein may hold the cure to liver cancer
Webbför 2 dagar sedan · This suggested that ATF4 protected against liver cancer in some way. Further experiments led by postdoctoral fellow Feng He, PhD, confirmed that ATF4 promoted the expression of SLC7A11, a protein ... Webb1 jan. 2024 · The ATF4 mRNA contains a 5′-UTR (untranslated region) region with various regulatory elements responsive to translational control ( 21) by eukaryotic translation initiation factor 2A (EIF2A). Without stress, EIF2A is not phosphorylated and ATF4 translation is low; under stress, EIF2A is phosphorylated on Ser51 and ATF4 translation … Webb19 nov. 2015 · Activating transcription factor 4 (ATF4) is a basic region-leucine zipper transcription factor that is widely expressed in many tissues and cells and functions as a stress response factor and a developmental regulator. 10 The absence of ATF4 induces partial perinatal lethality 11 and results in severe anemia and abnormal erythropoiesis in … ellen holly harry belafonte